Theoretically, both Delta 8 and Delta 9 THC interact with the same endocannabinoid receptors, meaning that they can produce cross-tolerance. Since Delta-8 is only half as powerful as Delta-9, people who use the latter extensively may not feel much of the former's effects until they take a break and reduce their tolerance. In 1974, researchers discovered that, instead of harming mice, Delta-8 THC had cancer-fighting properties. Under certain conditions, it may even be able to kill cancer cells.
Both Delta-9 and Delta-8 THC were used in the experiments. However, in 1975, subsequent studies revealed that Delta-8 THC could also reduce cancerous tumors. Cannabis and Delta 8 have very different tolerance windows. The active ingredient in cannabis is delta 9 THC, which is approximately twice as potent in its active effects.
This translates into a more intense experience and a much longer-lasting accumulation of tolerance. This delta 9 molecule only binds to one set of receptors in the endocannabinoid system, the CB1 receptors. This means that these receptors contain all of the THC bonds, leading to a kind of deeper saturation, where the accumulation persists long after the consumer has stopped using cannabis.